Study On Formulation Of The Qianlietong Watered Pill

Qianlietong tablet consists of Qianlietong extract, anise oil, cassia oil, amber ect. Add up to ten medicinal substances. Qianlietong tablet has being effective in clearing away the heat-evil and expelling superficial evils, regulating vital energy and promoting blood flow, eliminate inflammation and relieve pain, remove blood stasis lead urine easy and smooth that major curing acute and chronic prostatitis and hyperplasia of prostate and so on. The thesis should tablet change into watered pill and investigation on the extraction technology and preparation of Qianlietong watered pill at same time established quality standard.Experimental result indicate the optimum extraction technology of Qianlietong extract that extract solvent is water and extract times is twice. Each time is 2 hours extract and the first time water is 10 times, the second water is 8 times of medicinal substances mass. When volatile oil extract , first of all should crude medicinal substances were comminuted and sieving about 20 mesh. Heated and refluxing was 6 hours that gained volatile oil mass more than other methods. Preparation of watered pill used 75% alcohol asmoistening agent and added quality about from 25 to 28 percents of the prescribe mass. A reversed-phased HPLC methods was determine quality of berberine hydrochloride because the method simple, quickly, result accurate and reliability. Spectrum condition: mobile phase: acetonitrile 0.05mol/L and ADP (ammonium dihydrogen phosphate, compose of 0.03% triethylamine, use phosphonic acid adjust pH to 2.5. ratio 35: 65). Flow rate: l.Oml/min. Detect wave length: 345nm. The contents of berberine hydrochloride was 97.9159ug/pill(>0.045%). Average recovery was99.882%(RSD=1.2%).