The Distribution Of TCM Syndrome And Correlation With Western Medicine Index Of ET Et

Objective: To study frequency of syndrome distribution of patients with chronic renal failure in the four phase and relation between TCM syndrome differentiation and clinical objective indexes of western medicine. Methods: The 198 patients with chronic renal failure, According to the Guideline to clinical research of Chinese traditional medicine and new drug, will operate TCM differentiation typing while the level of serum ET, BUN, SCr and CCr was measured. Results: (1)The deficiency syndrome of spleen and kidney-qi with dampness and blood stasis occupied 48% in the first phase, And 24.1% in the second phase, And 10.3% in the third phase, And 1.96% in the fourth phase. The deficiency syndrome of both -qi and Yin with dampness and blood stasis occupied 40% in the first phase, And 25.9% in the second phase, And 7.7% in the third phase, And 9.8% in the fourth phase. The deficiency syndrome of spleen and kidney-yang with moisture and blood stasis occupied 0% in the first phase, And 15.5% in the second phase, And43.6% in the third phase, And 33.3% in the fourth phase. The deficiency syndrome of both Yin and Yang with moisture and blood stasis occupied 0% in the first phase,And 6.9% in the second phase, And 20.5% in the third phase,And 49% in the fourth phase. The deficiency syndrome of liver and kidney-Yin with dampness and blood stasis occupied 12% in the first phase,And 27.6% in the second phase,And 17.9% in the third phase, And 5.9% in the fourth phase. Meanwhile, There were significantdifferences among all kinds of affiliated syndromes.(2)the plasma ET and SCr level displayed the significant difference (p<0.01), while did not show any significant difference between the deficiency syndrome of spleen and kidney-qi with dampness and blood stasis groups and the deficiency syndrome of both -qi and Yin with dampness and blood stasis (P>0.05). The plasma CCr level did not show any significant difference between the deficiency syndrome of spleen and kidney-qi with dampness and blood stasis groups and the deficiency syndrome of both -qi and Yin with dampness and blood stasis, The deficiency syndrome of spleen and kidney-yang with moisture and blood stasis and The deficiency syndrome of both Yin and Yang with moisture and blood stasis(P>0.05). The rest of groups displayed the significant difference (p<0.01). The plasma ET level was positively correlated with the plasma SCr, BUN level (P<0.01)and negatively correlated with the plasma CCr. Conclusion: (l)The frequency of syndromes distribution of patients with chronic renal failure in the four phase displayed the significant difference. So did the affiliated syndromes. The patients with deficiency syndrome of both Yin and Yang with moisture and blood stasis may be the most serious than the others. Insufficiency of vital-Qi with dampness and blood stasis is one of features to patients with chronic renal failure.(2)The plasma ET, serum SCr, BUN and CCr may have relations with the TCM syndromes of chronic renal failure. The plasma ET level can serve as an objective parameter to determine TCM syndrome differentiation for the chronic renal failure.