Objective: To explore the changing concentrations of interleukin-10 (IL-10) and nitric oxide( NO) of type 2 diabetes mellitus patients for effects of nosogenesis in diabetic nephropathy.Subjective and Methods: The 40 cases type 2 diabetic mellitus patients diagnosed according to the criteria on diabetes mellitus of WHO in 1998, were on averagedivided into normal albuminuria group (UAER<20μg/min) and microamountalbuminuria group (UAER20~200μg/min). normal albuminuria group including 13 males and 7 females, microamount albuminuria group including 9 males and 11 females. 20 cases health adult subjects with matched gender, age and body mass index were regarded as normal control group. The subjects's serum level of IL-10 and NO used ELISA and nitric acid reducing enzyme means.Results: The microamount albuminuria group's serum level of IL-10 were low than the normal control group and normal albuminuria group(P<0.01), and serum level of NO were high than the normal control group and normal albuminuria group(P<.01). Conclusions: Serum contents of IL-10 of early-stage diabetic nephropathy patients were low, and Serum contents of NO of early-stage diabetic nephropathy patients were high. IL-10 and NO may lead to effect of early-stage diabetes nephropathy. |