Evaluate The Effects And Security Of Tinidazole Chip As A Treatment To Periodontitis

The aim of this study was to evaluate the efficacy and security of tinidazole chip as a treatment to periodontitis. This was a randonmized, double-blinded, parallel-arm study. 43 subjects with moderate to advanced periodontitis (at least one site 5mm≤ PD≤10mm with bleeding on probing (BOP )) were selected. They were randomly devided into two groups. they were give tinidazole chip and instructed the direction separately. The test group was 23 subjects and the control group was 20 subjects. The subjective symptom indexes (gingival bleeding ,gingival ache,occlude ache) and clinical indexes of probing depth (PD), gingival index (GI), bleeding index (BI), plaque index (PII) were measured at the 1-, 4-, 7-day. Subgingival bacterial samples were taken at the 1 -, 7-day for the observation of changes of bacteria. At the same time , The change of the number of leucocyte in blood were observed. And furthermore,the side effects of the tinidazole chip were monitored. At the baseline, the average ofeach indices and microbiological parameters between two groups was no differences. After treatment compared with baseline, the gingival bleeding ,GI and BI were decreased significantly (PO.05), the total number of subgingival microbe in two groups was also decreased significantly (P<0.05), but there were no statistically significant differences in the other indices . The number of leucocyte in blood was also no statistically significant differences. While there were no statistically significant differences between the two group.Based on these findigs, the tinidazole chip have some effects on the treatment of periodontitis. It was effective and secure medicine for treating periodontitis adjectively.