The Study Of Naloxone's Effect On Somatosensory Evoked Potentials Of Infarction

Objective: To evaluate the instant effect and mechanism of Naloxone for braininfarction with somatosensory evoked potentials(SEP).Methods: ninty-seven patients of acute cerebral infarction were divided intofive groups: striatocapsular group 37 patients;corone radiate group 18 patients;cortexgroup 11 patients;large cerebral infarction A group 17 patients(cortical potential N20elisited); large cerebral infarction B group 14 patients(cortical potential N20 notelisited). Naloxone 0.8mg was administered im,st. Then the different amplitudes ofN20 and CCT of SEP before and after treatment were analysed.Results: In the striatocapsular group, the N20 amplitudes elevated at the everypoint after treatment, significantly at the 30 minuates.In the cortex group and largecerebral infarction A group, the N20 amplitudes only elevated at the 30 and 50minuates after treatment. In the large cerebral infarction B group, the N20 recurrencewere found in all the patients. In the corone radiate group, the N20 amplitudeslowered significantly. The CCT only prolonged at the 40 minuates after treatment inthe corone radiate group;in addition, the CCT had no a variety at any point in othergroup.Conclusion: In short time, Naloxone is beneficial to the striatocapsular, cortexand large cerebral infarction patients;and can increase the cortical excitability of theabove infarction. At the same time, Naloxone decrease the cortical excitability oforone radiate infarction patients. Naloxone can not ameliorate nervous conductivity.