Regulation With Benefiting Stomach Prescriptions To Expression Of The Relevant Gene Proteins Of The Precancerous Lesions Of Gastric Cancer

Objective:As one of highest morbidity of malignant tumor, gastric cancer endangers people's health in China. The research on precancerous lesions of gastric cancer will be significant both in prevention and treatment of the disease. Because of the unknown of the cause of the disease, there is no satisfactory therapeutic way in modern medicine so far. Although TCM has made an impressive progress in the research of this field, there still remains a lot of problems, and without any break-through. Further TCM research needs to be carried out, especially through molecular biology, since most of the previous researches remain only in clinical reports or without any strict scientific designs.Through clinical observation and experimental research, the clinical symptoms and endoscope's signs have been observed, and the relevant gene proteins of the precancerous lesions of gastric cancer have been measured which guided the diagnosis and medicine in clinic of precancerous lesions of gastric cancer in TCM.60 cases of precancerous lesions of gastric cancer are divided into 2 groups at random, that is, Chinese herbal therapy group (observation group blow) and Hericium tablet on market sell in control group (control group blow), among which, 30 cases in observation group, and 30 cases in control group. Three month for one treat range, two treat ranges are observed. During being treated, the patiences were asked to stop using any medicines that can affect the clinical study. The clinical symptoms, endoscope's signs, tissue pathogenesis and the expressive condition of relative gene of stomach mucous membrane tissue ( ras primary cancer gene p21 and cancer suppressor gene p16), before and after treatment have been observed respectively. Result:1. The results of clinical experiment illustrate that the general effect of Chinese herbal therapy group is better than that of the control group.2. The evaluation on effect of endoscope discovered that in Chinese herbal therapy group the effective rate in the improvement of the sign of endoscope isobviously higher than those in control group, among which the improvement of granular proliferation and bill regurgitation becomes more obvious. The evaluation on pathogenic effect also discovered that in therapy group the atrophy of mucous membrane, enteromalacia, and the integral of parahyperplasia are obviously lower after treatment, which there is significant difference compared with that of the control group.3. The comparison with the infectious condition of pylorus spirilum found out that the positive rate of Hp infection after treatment in Chinese herbal therapy group decreased obviously, and with the significant difference compared with the control groups, which coincide with pathogenic reversion.4. In Chinese herbal therapy group, there is significant decrease in the expressive level of ras cancer gene p21 after treatment comparing with that before treatment, and also obviously decreased comparing with that in control group after treatment, which clearly illustrated the patients suffering from prophase of carcinoma of stomach had higher expressive level of ras cancer gene p21, and Chinese herb benefiting stomach prescriptions can obviously decrease its expressive level.5. In Chinese herbal therapy group, there is significant increase in the expressive level of cancer suppressor gene pi6 after treatment comparing with that before treatment, while there was no significant change in the control group, which clearly showed the expressive level of cancer suppressor gene pi6 in patients suffering from prophase of carcinoma of stomach decreased, and Chinese herb benefiting stomach prescriptions can obviously increase its expressive level.Conclusion:1. Advance the hypothesis of traditional Chinese medicine symptom to change regularity in the prophase of stomach cancer .According to the relation of healthy qi > pathogenic factors, asthenia, sthenia, we regard, the disease is developing by sthenia of pathogenic factors - asthenia of helthy qi and sthenia of pathogenic factors-asthenia of helthy qi , in the prophase of the disease ,it is mainly blood stasis and pathogenic heat and toxin(sthenia of pathogenic factors); in metaphase ,the character of the disease is mostly asthenia of yin and pathogenic heat (asthenia of helthy qi and...