Change Of ROS And Significance In Patients With Acute Respiratory Infective Disease

Respiratory system was invaded easily by bacterium because of its anatomy characteristic, which induced the increase of the total mortality rate of respiratory infective disease, especially the children pneumonia in behindhand country and region, the elderly pneumonia which was caused by population aging and pneumonia which accompany with severe basic diseases or immunity feebleness. Acute respiratory infective disease was only inferior to cardiovascular disease according to the population death reason which was investigated by WHO all over the world, the increase of incidence of a disease and mortality of respiratory infective disease had consanguineous relation with the variance of pathogenic and the diagnosis difficulty of pathogeny. How to diagnose infective disease frequently, instruct clinical therapy and shorten the period of treatment of disease was a hotspot at present. Some investigation had indicated that ROS was important in the occurrence and development of inflammation. To discuss the relation of ROS and infection was important to the forepart diagnosis and clinical therapy of acute respiratory infective disease. We monitored the 75 patients who came to respiratory department in the third medical college of JiLin University during 2004-2005, the patients were divided into 3 groups:30 cases were acute pneumonia patients, 18 cases were men, 12 cases were women, they were 21 to 54 years old, the mean age was 43.7 years old, They were answered for"the diagnosis standard and therapy manual of community acquired pneumonia "which was established by Respiratory Disease Union of Chinese Medicine Union; 24 cases were acute upper respiratory tract infection, 11 cases were men, 13cases were women, they were 20 to 48 years old, the mean age was 40.8 years old; 21 cases were healthy control, 12 cases were men, 9 cases were women, they were 24 to 50 years old, the mean age was 42.5 years old, they were excluded from acute or chronic infection, heart, liver and kidney primary diseases, tumor and immunity diseases. Three groups had no distinct difference in age, sex (P>0.05).All data was delivered through means value ±standard errand( ).We analyzed the three groups through t test, it has significant difference when P<0.05.In this investigation, we found that the serum ROS was increased distinctly in the acute pneumonia patients than in the acute upper respiratory tract infection and control before the stimulation of PMA, the difference was significant(P<0.01); the serum ROS was increased distinctly in three groups after the stimulation of PMA, but the serum ROS was increased distinctly in the acute pneumonia patients than in the acute upper respiratory tract infection and control, the difference was significant(P<0.01);the dispersion of the serum ROS was increased distinctly in the acute pneumonia patients than in the acute upper respiratory tract infection and control before and after the stimulation of PMA, the difference was significant(P<0.01),the serum ROS in acute upper respiratory tract infection was between in acute pneumonia and control, which had statistic meaning. The serum ROS can be an important index of forepart diagnosis of respiratory acute infective disease, and distinguish between bacterium infection and virus infection. ROS was accompanied with infection, they promoted each other to vicious circulation. At last, the reflection of respiratory to many stimulants increased. It...