Expression Of Nuclear Factor κB And The Effect Of Tripteryginm Hypoglaucum On Lichen Planus Lesion

Summary: To study the function of NF-κB in pathogenesis of LP and the effect of Tripteryginm hypoglaucum on expression of NF-κB in lesional LP skin. The expression of NF-κBP65 in 20 normal skin and 45 LP skin were examined by immunohistochemistry. Positive staining in lesion was distributed in the basal and suprabasal epithelial cells, brown-yellowish staining was observed in cell nucleus, while normal epithelium was consistently negative. Compared with the normal skin, the positive rate and the mean expression level of NF-κBP65 in lesions of LP were significantly higher (P<0.05). After using Tripteryginm hypoglaucum for two months, nuclear NF-κBP65 expressed on basal and suprabasal keratinocytes were lost and decreased. Positive staining of NF-κB in the lesions of patients with LP may play a partial role in the pathogenesis of LP. Tripteryginm hypoglaucum may directly or indirectly inhibit NF-κB nuclear expression in keratinocytes and may be available in the treatment of LP.