Repair Of Bone Defect With Chitosan/hydroxylapatite/BMP Complex

Objective: To investigate the feasibility of chitosan/hydroxylapatite/BMP complex as bone substitute material and carrier of BMP.Methods: Porous chitosan/hydroxylapatite and chitosan/hydroxylapatite/BMP complex were implanted into calvarial defects. On 2,4,6 and 8 weeks after operation bone repairing ability was assessed by radiographic and histological observation.Results: Chitosan/hydroxylapatite/BMP complex had an excellent manipulation , shaped ability , biocompatibility, a small influence in body microenvironment, a good mineralization effect on surfaces. The complex had greater bone repairing ability than others alone.Conclusion: Chitosan/hydroxylapatite/BMP complex may be used as a bone substitute material and carrier of BMP.