Mini-invasive Aspiration For Middle-volume Spontaneous Basal Ganglia Hemorrhage: A Randomized Controlled Trial

Objective: To compare the clinical effect of the mini-invasive aspiration with conservative medical treatment in treating patients with 25~40ml spontaneous basal ganglia intracerebral hemorrhage.Methods: The study was a part of "the research of evaluating the clinical effect and cost of hospitalization in treating intracerebral hematoma with mini-invasive aspiration", which was a multi-center, randomized controlled research subject of Ministry of Health. Patients were randomly divided into "Aspiration group" and "Conservative group". The Scandinavian Stroke Scale (SSS) score in the 14th day, modified Rankin Scale (MRS) score in the 14~th and 90~th day, Barthel Index (BI) score, the rebleeding rate and mortality in the 90th day were used as the evaluating parameters.Results: Twenty-nine patients were involved in the study, 15 of them in Aspiration group and 14 of them in Conservative group. There was no significant difference between the two groups about the SSS score and MRS score in the 14~th day (P>0.05). In the 90th day after the therapy, the Aspiration group showed a remarkable improvement in MRS score and BI score (P<0.05). Taking the BI score < 60 as a remark of significant life dependency, the outcome of the Aspiration group were much better than that of Conservative group at the end of the study (0 vs. 41.7%, P=0.012). In the 90~th day of the study, no significant difference between the two groups in the rebleeding rate (6.7% vs.7.1%, P=1.000) and mortality (6.7% vs. 14.3%, P=0.598) was found.Conclusions: Compared with conservative therapy in treating 25~40ml spontaneous basal ganglia intracerebral hemorrhage, the mini-invasive aspiration therapy remarkably improved the patients' activities of daily life, decreased their dependency rate, indicating that the mini-invasive aspiration is a safe and effective method.