Effects Of The Formula Of Invigorating Qi, Warming Yang And Activating Blood Circulation To Dissipate Blood Stasis On Apoptosis In Vascular Smooth Muscle Cell After Angioplastry

Objective: To observe the effect of the formula of invigorating qi warming yang and activating blood circulation to dissipate blood stasis on apoptosis in the rabbits whose endangium of carotid are injured and to investigate its mechanics of preventing the restenosis after the percutaneous transluminal angioplastry, then to provide a thereunder to guide the clinic further.Methods :Replicating the animal model of restenosis after percutaneous transluminal angioplastry for experimentation with injury by balloon .We devided the models to the model control group and the Chinese traditional medicine prevent group random. There are 18 rabbits in each group.we take another 18 rabitts as the bogus operation group.Each group are divided into 3 time points as 1w, 2w, 4w.To observate the effects of the Chinese traditional medicine to the restenosis degree of the carotid, the luminal area of the carotid , the sum of the endangium and the tunica media, the apoptosis of the smooth muscle cell with the methods of carotid angiography, Pathology and immunohistochemistry.Result: Contrasted with the bogus operation group, the abnormal of the pathologic picture and ultrastructure and the restenosis degree of the carotid aggravated significantly of the model control group and the Chinese traditional medicine prevent group.And their sum of the endangium and the tunica media accretived significantly. Contrasted with the model control group,the luminal area accretived significantly. Its restenosis degree of the carotid and the sum of the endangium and the tunica media decreased. The apoptosis of the smooth muscle cell were increased significantly.But its pathological changes were severer than the bogus operation group.