The Clinical Study Of Glutamine's Protection Effect In Severe Burned Patients With Sepsis And MODS

Objective: We measured the changes of variables of Glutamine, endotoxin, TNF-a and IL-2' s level in plasma and pHi in order to investigate the protection effect of Glutamine' s in severe burned patients with sepsis and MODS by againsting endotoxin. The possible principle was also discussed.Methods: 32 adults severe burned patients whose total burned surface area were 30%-50% or III°20%-40% without inhalation injury were randomly divided into 2 groups. 16 patients in therapy group were treated according to the same procedure as that of Control group and Gln (0. 5g/kg) by a stomach catheters for 2 weeks. Cardiopulmonary variables, blood cell regular variables were measured according to the schedule. Hepatic and renal function, the concentration of Gln, endotoxin, TNF-a and IL-2, pHi (the pH value of intra-mucous membrane of gut). The rate of sepsis and MODS of 32 patients was compared between two groups. The patients' hospital stay days were recorded. SPSS 11. 0 system was used for the analysis of data.Results: After burn injury the concentration of Gln was significantly decreased, the concentration of Gln in plasma in Gln group was significantly higher than that of Control group (p<0. 01), It was nearly reached normal level at 7th day, the concentration of Gln came to reach...