Study Of Correlation Between Plasma Plasminogen Activator Inhibitor-1 Level And Insulin Resistance With Dyslipidemia

Objective To detect the plsma plasminogen activator inhibitor 1(PAI-1) levels in obesity and type 2 diabetes mellitus(DM) without obesity and type 2 diabetes mellitus with obesity,and explore the correlation between PAI-1 and insulin resistance,blood glucose,insulin,lipids etc. Methods To assay plasma PAI-1 of obesity and type 2 diabetes mellitus without obesity and type 2 diabetes mellitus with obesity and normal control with enzyme-linked immunosurbent assay(ELISA),and messure body mass index(BMI), waist hip ratio(WHR),blood glucose,fasting insulin and lipids.To evaluate insulin resistance with Homa Momel and measure insulin sensitivity index(ISI). Results (1)The plasma level of PAI-1 was significantly increased in obesity,type 2 DM without obesity and type 2 DM with obesity compared with normal control(P<0.05～P<0.001). There was no difference between type 2 DM without obesity and type 2 DM with obesity,and the plasma PAI-1 in type 2 DM with obesity and type 2 DM without obesity was significantly higher than obesity (allP<0.05).(2)HOMA-IR in 3 groups was significantly higher than nomal control ( P<0.05 ～ P<0.001 ) , HOMA-IR in type 2 DM with obesity was significantly higher than obesity and type 2 DM without obesity.(3)In a general multivariate regression ,HOMA-IR,fasting insulin,BMI,serum triglyceride and low density lipoprotein cholesterol were significantly independent determinants for plasma PAI-1(all P<0.001). Conclusion (1)Plasma PAI-1 is significantly increased in obesity,type 2 DM without obesity and type 2 DM with obesity.(2)Plasma PAI-1 is positively correlated to HOMA-IR,and is correlated with BMI,serum triglyceride,fasting insulin and low density lipoprotein cholesterol.The increasing of PAI-1 is the result of metabolism disorder with hyperinsulinism,high triglyceride and hyperglycemia.PAI-1 is the bridge between obesity and insulin resistance.PAI-1 is one of evalution marker of insulin resistance.(3)Anti-PAI-1 study maybe a new way to prevent obesity and insulin resistance.