Clinical Efficacy And Pharmacokinetics Of Paravertebral Repivacaine For Thoracotomy Analgesia In Children

Objective: Posterolateral thoracotomies are among the most painful interventions satisfactory analgesia is therefore necessary to enable patients to perform intense postoperative respiratory physiotherapy and to reduce pulmonary complications. Thoracic paravertebral block is effective in controlling post-thoracotomy pain, but which is not widely used in children. Ropivacaine have several properties, which may be useful in pediatric practice. Information about the pharmacokinetics of ropivacaine following TPVB in children is lacking. In the present study, we measured plasma concentrations of ropivacaine following intraoperative TPVB. Determined the clinical efficacy and pharmacokinetics of a single injected ropivacaine. Methods: this study was done on 6 patients undergoing thoracotomy. Each received thoracic paravertebral a single injected ropivacaine 0.375%, 0.7ml/kg. The time of obtained initial effect and full effect, lasting time sensory blockade segment were measured .Plasma concentrations of ropivacaine were measured through high-pressure liquid chromatography and side effects were recorded. Results: The time of obtained initial effect and full effect,...