Clinical Analysis Of Primary Biliary Cirrhosis: A Report Of 78 Cases

Objective Clinical, immunological and pathological features of primary biliary cirrhosis(PBC) were reviewed in order to improve its diagnosis and treatment.Methods The general conditions, clinical manifestations, biochemical and immunological changes, and pathological fingings were assessed in 78 patients. Of these patients, 19 underwent hepatic biopsy.Results Seventy cases were females, the mean age at definite diagnosis was 46 years. The period from occur to definite diagnosis was 1-480 months. 20 cases had not typical manifestations at definite diagnosis(25.6%). Typical manifestations such as pruritus(46. 2%), hepatomegaly(32. 1%), splenomegaly(33. 3%) and jaundice(82. l%).The serum level of total billrubin was gradually increased along with progression of PBC. The level of Alkaline transpeptidase(ALP) and Gammaglutamgl transpeptidase(GGT) rose at the early stage. The positive rate of Antimitochondrial antibody (AMA)was 88. 5% and that of M₂ 75. 6%. As for 19 patients receiving hepatic biopsy, 19 cases were AMA negative. Ursodeoxycholic acid (UDCA) was effective.Conclusion In our nation, major patients of PBC were also female, and they may have no typical manifestations at definite diagnosis .The prognosis may be worse in the patients with jaundice. To further confirm that the importance of AMA-M₂ in the diagnosis of PBC, and UDCA in the therapy of PBC .