Study On Chemokine Receptors And Immune Function Of Th Lymphocyte In The Patients With Condyloma Acuminatum

Immunohistochemistry, flow cytometry and ELISA were respectively used to study the expression of CCR1, CCR3, CCR5 and CXCR4 on the cells of wart tissues excised from the patients with condyloma acuminatum (CA), the expression of CCR1, CCR3, CCR5 and CXCR4 on peripheral blood CD3~+ T-Lymphocytes and the levels of MIP-1α, MIP-1β, RANTES, IL-2, IFN-γ, IL-10 and IL-4 of the serum in the patients with CA. Among forty-eight recurrent patients, the expression of CCR5 and CCR3 was first detected on the wart tissues excised from nineteen and eleven patients respectively and the expression of both CCR5 and CCR3 was detected on the wart tissues excised from five patients. The levels of MIP-1α, MIP-1β, IL-4 and IL-10 of the serum in the patients were significantly higher than those of normal controls and The levels of IL-2 and IFN- γ of the serum in the patients were significantly lower than those of normal controls. There were no difference in the level of RANTES and the expression of CCR1, CCR3, CCR5 and CXCR4 on peripheral blood CD3~+ T-Lymphocytes between the patients and normal controls. The expression of CCR3 and CCR5 on the wart tissues excised from recurrent patients and the increase of levels of MIP-1α and MIP-1β may be related to the decreased immune function and immune escape of virus. The increase of IL-4 and IL-10 and decrease of IL-2 and IFN- γ indicated the decreased immune function in human body. The study may have some significance to discover the mechanism of recurrence of CA and immune escape of virus.