Expression Of P16, CyclinD1 And P27 In Human Bladder Cancer And Its Clinical Significance

Objective To study the expression of P16, CyclinD1 and P27 and their significance in human bladder cancer. Methods Immunohistochemical technique S-P was used to study the expression of P16, CyclinD1 and P27 in 69 cases of human bladder cancer and 12 cases of normal bladder. Results The positive expression rates of P16, CyclinD1 and P27 are 43.5%, 59.4% and 31.9% in bladder cancer, and 100%, 16.7% and 75.0% in normal bladder mucosa. Their expression rates showed significant difference between normal bladder mucosa and bladder cancer(p<0.01); with the increasing of pathological grade and clinical stage of bladder cancer, the positive expression rates of p16 and p27 decreased, while the positive expression rate of cyclinD1 increased. Conclusions The abnormal expression of P16 CyclinD1 and P27 played an important role in the genesis and progression of human bladder cancer.