| Objective:To study the relationship between plasma LPS,histamine and Th1/Th2 cytokines in patients with hepatitis B virus (HBV) infection ;To further explore wether they have influence to immunological function. Method:The plasma and serum were collected from patients with chronic HBV infection and normal human . The level of plasma histamine,LPS ,the activity of serum complement,trptase,Th1/Th2 cytokines such as IL-2,IL-4,IL-10,IL-12,IFN-γwere examined. Based on the classification of the hepatitis B, the correlation of the ET,histamine and Th1/Th2 cytokines was analysed. Result: (1) Compared with the normal people,the patients with HBV infection has a significantly increase of IL-4 ,IL-10, and a significantly decrease of IL-2,IL-12,IFN-γ. (2) The serum IL-4 ,IL-10 contents in patients with IETM were significantly higher than that of the patients without IETM. The serum IL-12 contents in patients with IETM were significantly lower than that of the patients without IETM. The serum IL-2,IFN-γcontents in patients with IETM were lower than that of the patients without IETM. (3) Compared with the increase of plasma histamine, there has a significantly decrease of the serum IL-12,IFN-γ. (4) There has a positive correlation between trptase and Th1 cytokines such as IFN-γ,IL-2. (5) ET has a significantly positive correlation to AP50. Conclusion:There all are Th1/Th2 imbalance of different gradients in patients with chronic HBV infection. Endotoxin and histamine are correlate with immunological function ,but they produce a marked effect in different ways. Endotoxin make Th2 cytokines increased,while histamine make Th1 cytokines decreased.
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