The Role Of Gastrin In The Progression Of Colon Cancer

PrefaceIn 1996, Kinzler et al developed the paradigm of adenoma - cancer sequence of colorectal carcinogenesis. According to the paradigm, some colon cancer cells come from normal raucoma, However, most cases of colon cancer evolved from colon adenoma. Many clues support the major mechanism that colon cancer happens lies in adenoma - cancer sequence.Although the sequence are accepted by most doctors , Dongjun believed that dysplasia of colon mucoma was the direct precancerous lesions of colon cancer. Recently, workers found gastrin could promote proliferation of colon cancer cells. In addition, some docters thought that the activation of gastrin gene could be an early event of colorectal carcinogenesis, and may be important for the progression of cancer.The proliferating cell neclear antigen ( PCNA) gathers more coenzyme for DNA. PCNA can lie in normal proliferating cells and cancer cells. It can present the character of cell proliferation.The expression of gastrin and PCNA were measured in normal colon mucoma , dysplasia, adenoma, cancer, to probe into the role of gastrin in the progression of colon cancer.Materials and MethodsAll specimens were obtained from 2004. 01. 01 to 2004. 10. 16 in the pathology department of the 2nd hospital of China Medical Univercity. Among them,there are 30 specimens for colon cancer, 15 for adenoma, 15 for dysplasia, 15 for colon normal mucoma.