The Effects Of Anti-neurohormone Treatment On Neurohormones And Ventricular Remodelling Of Myocardial Infarction Patients Companied By Diabetes Mellitus

Objective: Through application beta-receptor blocking agent and angiotensin-converting enzyme inhibitor or angiotensin receptor blocking agent , To explore the characteristic of ventricular remodelling and heart function and the plasma concentrations of neurohormone of myocardial infarction patients accompanied by diabetes mellitus, thus provid evidence for prevention and treatment heart failure for myocardial infarction patients accompanied by diabetes mellitus.Methods: myocardial infarction patients accompanied by diabetes mellitus who were inhospital from February 2002 to july 2004 were randomly selected as diabetes group ,at the same time , myocardial infarction patients who did not accompany diabetes mellitus were choosed at random as contrast group, all patients were given beta-receptor blocking agent and angiotensin-converting enzyme inhibitor or angiotensin receptor blocking agent ,and then were followed up one year. Before treatment and 6 months after treatment ,the plasma renin activity (PRA),the plasma concentration of angiotensinâ…¡(Angâ…¡),aldosterone(Ald),norepinephrine(NE) and epinephran(E) were measured. Meanwhile ,left ventricular end-diastolic diameter(LVEDD), left ventricular end-systolic diameter(LVESD) , left ventricular end-diastolic volume(LVEDV) ,left ventricular end-systolic volume(LVESV) and left ventricular ejection fraction(LVEF) were detected before treatment and 3 months, 6 months and 1 year after treatment. ventricular remodelling and the plasma concentrations of neurohomone were compared before and after...