Blue-on-yellow Perimetry In Early Diagnosis Of Diabetic Retinopathy

ObjectiveTo probe into early diagnostic value of blue-on-yellow perimetry (BAT) in diabetic retinopathy(DR). MethodsWe adopted prospective clinical design and contrast study.Control group comprised 10 non diabetes mellitus (DM) (20 eyes) and diabetic group comprised 30 type 2 DM (60 eyes).Diabetic group were separated into two groups according to retinopathy degree. The patients who have no diabetic retinopathy(NDR) belonged to NDR group and the others belonged to DR group. Diabetic group were also separated into two groups according to control degree of blood suger. Group A include the patients whose glycated hemoglobin (HbAlc) was lower than 7% and Group B include the patients whose HbAlc was higher than 7%. Diabetic group were also separated into three groups according to the course of DM. Group I included patients whose course of DM was in 5 years. Group II included patients whose course ofDM was in 10 years. Group â…¢ included patients whose course of DM was at least 10 years.Each subjects underwent visual or corrective visual examination, intraocular pressure measurement, fundus examination, white-on-white perimetry (WAVP), blue-on-yellow perimetry(B/YP) with OCTOPUS 101 automatic perimetry produced by Switzerland and 30 type 2 DM were received fluorescence angiography(FFA) and HbAlc test in addition. We recorded 5 perimetry index: (l)Mean Defect(MD)(2)Mean Sensitivity (MS) (3) Loss Variance(LV)(4)Corrected Loss Variance (CLV) (5) Short-term Fluctuation (SF).All the dates were maneged with SPSS10.0 for window. ANOVA analysis and independent-samples t test were used. Results1. The difference between the mean ages of all compare groups was not significant(P>0.05).2. The condition of WAVP1) The difference of MS between control group and NDR group had statistical significance(P<0.05). The difference of MS between control group and DR group had statistical significance (P < 0.01). The difference of MD and LV between control group and DR group had statistical significance(P<0.05).2) The difference of MS and MD between group A and group B indiabetes group had statistical significance (P<0.01).3) The difference of MS and MD between group I and III had statistical significance (P<0.01). The difference of MS and MD between group II and III in diabetes group had statistical significance(P<0.05).3. The condition of B/YP1) The difference of MS ,MD, LV between control group and NDR group, control group and DR group had statistical significance (P<0.001). And the difference of CLV between them had statistical significance (P <0.01). The difference of MS and MD between DR group and NDR group had statistical significance (P< 0.001=.2) The difference of MS and MD between group A and group B had statistical significance (P<0.01).3) The difference of MS and MD between group I and group HI had statistical significance (P<0.01). The difference of MS and MD between group I and group II, group II and group HI had statistical significance(P<0.05).Conclusions1. B/YP can indicate the early changes of optic function of the diabetic. And B/YP can inflect the visual field defect of NDR patients, while W/WP can not. So B/YP has potential clinical application value in early diagnosis of diabetic retinopathy.2. There was good coincidence between W/WP and B/YP.3. The visual function of type 2 DM had damaged before diabetic retinopathy. Type 2 DM not only have regular photosensitivity descend, but have diffuse or limited visual field defect.4. The degree of visual field defect in type 2 DM highly related the level of blood sugar, the degree of diabetic retinopathy and the period of diabetes.