Finite-Element Analysis Of Electromagnetic Field And Temperature Field For Treatment Human Tumor With Magnetic Fluid Hyperthermia

Magnetic Fluid Hyperthermia technology was still investigated decades later and was concerned popularly. It was found that this technology was much effective in combination therapies in respect that it had some unique characters such as universality, high specific absorption rate, thermal bystand effect, dimension targeting effect and magnetic nanoparticles' oriented ability in clinic treatment. In despite of these characters, any clinical implement was far behind the horizon. Some possible reasons counteracting the application included poor AC magnetic field applicator, inexact thermometry and so on. The two problems metioned above were discussed in this thesis.First, the electromagetic field needed by MFH devices was calculated rudimentarily. And then, an AC magnetic applicator was designed and manufactured by local reseachers. After that, static and transient analyses were finished that the detailed distribution of electromagnetic field in the AC magnetic applicator was calculated. Results which including some parameters such as magnetic intensity and inductance of coils agreed with experimental measurements, which clarified the variational discipline of each parameter in electromagnetic field and the relations of every characteristic parameter and dimensions of devices. When the atmosphere spacing changed, homogeneity of magnetic field between spacing was evaluated. In order to accomplish the clinical treatment system in the future, the large-scale magnetic core-coil was discussed, and an application program was developed to cooperate with ANSYS taking accout of other researchers' convenience.As another aspect of this thesis, some temperature experiments were carried out. The temperature of tissues in vitro was measured in AC magnetic field after magnetic fluid was injected into them by fine resolution thermometer. And then ANSYS was used to investigate the feasibility of applying the data to model Pennes' temperature distribution. Some related problams in clinic treatment were discussed.