Study On The Chronic Oral Toxicity Of 50.5 Percent C₁₇H₂₂N_2O4

Objective:To study the chronic oral toxicity of 50.5 percent C17H22N2O4. Method: SD rats were given C17H22N2O4 which is added into the forage of 0,44.05,135.65,540.75 mg/kg/d for 180 days. General condition, body weight,the main organic indices (heart, liver, kidney, brain, spleen, lung and spermary, ovary). 不lood indices (RBC, HCT, MCV, HB, MCH, MCHC, PLT, WBC).biochemical indices (ALT, AST, ALP, TP, ALB, GLB, A/G, LDH ,T-BIL, CRE, BUN,) tissue slide was observed under light microscope. Results: At the end of the test ( 180 days after starting), some visceras(heart, liver, kidney, brain, spleen, lung and spermary, ovary) in the group of 540.70mg/kg/d showed abnormal manifestation. some visceras(heart, liver, kidney, brain, spleen, lung ) in the group of 135.65mg/kg/d are abnormal.After the test, the body weight of male animals in the 540.75 mg/kg/d group decreased,GLB in the group of the 540.70 mg/kg/d drop,A/G in the 540.75 mg/kg/d had significantly increased compared with the group of the 0 mg/kg/d.Lung index and ovary index in the group of 540.70 mg/kg/d increased,heart index in the groups 135.65 and 540.75 mg/kg/d increased. After 90 days the test was started, some visceras(heart, liver, kidney, brain, spleen, lung) in the group of 540.70mg/kg/d showed abnormal manifestation. some visceras( kidney, brain, spleen, lung) in the group of 135.65mg/kg/d are abnormal.Spermary indices in the groups of 135.65 and 540.75 mg/kg/d increased. Body weight in the groups of 135.65 and 540.75 mg/kg/d decreased. However, during the period of test all indices of the groups 44.05 mg/kg/d were normal. Conclusion: According to "Assessment of the chronic oral toxicity result of the rat"(GB15670-1995), in the chronic oral test ,.the maximum non-effective dose of 50.5 percent C₁₇H₂₂N_2O4 in SD rat is 44.05 mg·kg^-1·d^-1...