The Disscuss Of The TNF-α,IL-8,IFN-γ Effect Of ITP Complicated By HP Infection

Objective: To compare the cytokines TNF-α , IL-8, IFN- γ before and after the eradication of HP infection in patients with ITP.and to explore the relation of the three cytokine and the platelet count.Methods: We selected 40 patients of the ITP complicated HP infection,half of which(A₁ group)are given HP eradication treatment,while the others(A₂ group) aren't given.30 ITP patients of the HP negative are taken as B group.30 healthy peoples are taken as C group. The ¹⁴C urea breath test(¹⁴C-UBT) was utilized to diagnose of HP infection.Before and after the treatment,TNF-α, IL-8 , IFN-γ are measured by the ELISA method.The effect of the three cytokines to platelets is observed.Result :(1)Campared the TNF-α, IFN-γ and IL-8 of groups,A₁ group showed TNF- α, IFN-γ significantly higher than the B and C group(p<0.05) .The thirty and the sixty day ,A₁ and A₂ groups also showed very significantly change(p<0.05) of the TNF-α, IFN- γ while the IL-8 of the patients don't have much change (p>0.05).(2) After the HP treatment ,the platelet count of ITP patients complicated HP infection rose significantly (p<0.05).(3)The platelet count and TNF-α, IFN- γ of the A₁ group showed obvious negative correlation.Conclusion: Part of the ITP patients are related to the TNF-α, IFN-γ ,which are released after HP infection. So the HP treatment is an important addition to the ITP treatment.