Expressions And Significance Of Survivin,PTEN Proteins In Human Lung Cancer | Posted on:2006-09-24 | Degree:Master | Type:Thesis | Country:China | Candidate:W Q Bao | Full Text:PDF | GTID:2144360152498991 | Subject:Internal Medicine | Abstract/Summary: | PDF Full Text Request | Objective To study the expression of Survivin and PTEN protein in human lung cancer and their relationships to the biological behavior of lung cancer.Methods An immunohistochemical method (PV-9000 Polymer Detection System For Immuno-Histological Staining) was used to detect the expressions of Survivin, PTEN proteins in 65 cases of lung cancer, 10 cases of adjacent tumor tissues and 8 cases of benign pulmonary disease tissues. SPSS 11.5 statistic software was applied to analyze the data.Results (1) The positive expression of Survivin protein was 70.77% (46/65) in lung cancer. It was negative in adjacent normal lung tissue samples and in benign pulmonary disease tissues. It was 78.85% (41/52) in non-small cell lung cancer (NSCLC), 38.46% (5/13) in small cell lung cancer (SCLC). There was a significant difference between in non-small cell lung cancer and in small cell lung cancer (P<0.01). 77.78% (21/27) in squamous cell carcinoma, 80% (20/25) in adenocarcinomas. There was no significant difference between in squamous cell carcinoma and in adenocarcinomas (P>0.05). The positive expression of PTEN protein was 49.23% (32/65) in lung cancer, It was 90.00% (9/10) in adjacent normal lung tissue samples and 100.00% (8/8) in benign pulmonary disease tissues. There was no significant difference between in adjacent normal lung tissue samples and in benign pulmonary disease tissues (P>0.05). It was 48.08% (25/52) in non-small cell lung cancer, 53.85% (7/13) in small cell lung cancer. There was no significant difference between in non-small cell lung cancer and in small cell lung cancer (P>0.05). It was 55.56% (15/27) in squamous cell carcinoma and 40% (10/25) in adenocarcinomas. There was no significant difference between in squamous cell carcinoma and in adenocarcinomas (P>0.05). The significant relationship was observed between in adjacent normal lung tissue samples and lung cancer (P<0.01), The significant relationship was observed between in benign pulmonary disease tissues and lung cancer too (P<0.05). There was no significant difference in the groups of clinical stage for Survivin expression. The positive expression of PTEN is associated with clinical...
| Keywords/Search Tags: | Pulmonary carcinoma, Survivin protein, PTEN protein, Immunohistochemistry | PDF Full Text Request | Related items |
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