Expression And Clinical Significance Of Survivin, P53 And C-myc In Esophageal Squamous Carcinoma

Objective To study the expression of Survivin, P53 and C-myc and their clinical significance in esophageal squamous carcinoma(ESC). Methods The expression of Survivin, P53 and C-myc was detected immunohistochemistrically by Power Vision ?-9000 (PV-9000) and SP methods in 60 cases of ESC, 15 cases of esopgaeal benign tumor (EBT) and 10 cases of adjacent normal esophageal mucosa. Results Survivin was mainly expressed in cytoplasm and ocassionaly expressed in nucleus. P53 was expressed in nucleus. C-myc was mainly expressed in nucleus, and also could be found in cytoplasm. The positive rate of Survivin, P53 and C-myc in ESC, EBT and adjacent normal mucosa were 71.67%, 13.33%, 0; 65.00%, 0, 0; 61.67%, 13.33%, 0, respectively. The differences of Survivin expressive rate b etween ESC and adjacent normal mucosa, EBT were all obviously significant (q=-5.0510, -5.9711; P<0.01, 0.01), but was not significant between adjacent normal mucosa and EBT (q=-1.1075, P>0.05). The expressive rate of P53 was also signicantly different between ESC and adjacent normal mucosa, EBT (q=-4.6039, -8.0362; P<0.01,0.01),but was not significant between adjacent normal mucosa and EBT(q=-0.4783. P>0.05). It was the same with C-myc expressive rate between ESC and adjacent normal mucosa, EBT (q=-4.3880, -4.9339; P<0.01, 0.01), between adjacent normal mucosa and EBT(q=-1.0175, P>0.05). Among the different histopathological grade groups, the expressive intensity of Survivin, P53 and C-myc were all significantly different (Hc=8.3586, 7.4224, 13.2451; P=0.0202, 0.0322, 0.0023); Among the different clinical stage groups, the expressive intensity of Survivin, P53 and C-myc were also significantly different(Hc=16.0344, 14.1579, 15.3602; P=0.0018, 0.0044, 0.0028); Between the two groups of lymph node metastasis or not, the expressive intensity of Survivin,P53 and C-myc was significantly different (Hc=3.2734, 2.2377, 2.3028; P=0.0011,0.0213 , 0.0252). The expressive intensity of Survivin, P53 and C-myc became strong, along with the decreased histopathological grades, the increased clinical stages and lymph node metastasis. No significances were found between the expressive intensity of Survivm, P53 , C-myc and the location of ESC(Hc=0.0744, 0.5888, 0.5093;P=0.9659, 0.7615, 0.7921) . It was the same between the expressive intensity of...