Age And Family History Of Chinese Adults Insulin Secretion And Insulin Action

Part1. Ageing related changes of insulin secretion and insulin sensitivity among normal glucose tolerance individuals in ChinaObjective: To investigate ageing related changes of insulin secretion and insulin sensitivity among normal glucose tolerance (NGT) individuals in China.Methods:34239individuals were included in the analysis, all of which were described as NGT by75g oral glucose tolerance test (75gOGTT) according to the diagnosis criterion of WH01999. Homa-B, AI30/AG30,IiisAuc30/GIuAuc30,1nsAiic120/G1uAuc120were calculated to estimate insulin secretion; Honia-IR and Matsuda index were calculated to estimate insulin sensitivity; Dispositon index: Homa-B/Hoina-IR,D130and D1120were calculated to estimate13-cell function.Results: In univariate linear regression, Homa-B, AI30/AG30InsAuc30/GluAuc30and Homa-IR were negatively correlated with age, Matsuda Index was positively correlated with age among men and overall, while no correlation was found between Horna-IR/Matsuda Index and ageing among women. In mutilivariate linear regression, the results among men and overall still existed after adjusted for BMI and waist circumference; while there was no correlation between Homa-B and ageing among women, Matsuda Index was positively correlated with age and Homa-IR were negatively correlated with age among women after adjusted for BMI and waist circumference. No linear correlation was found between Homa-B/I loina-lR and agcing, D130and D1120were negatively correlated with age in both uni',-0Mriate <<nd Iuutilivariate lincar re}-,ression.Conclusions: The basal insulin secretion amount is lower in elder groups among NGT individuals in China, but this relation disappears after adjusted for insulin resistance. The early phase and total insulin secretion postchallenge decreases with ageing even after adjusted for insulin resistance. Hepatic and overall insulin sensitivity does not deteriorate with ageing and its related change of body composition and weight gain. Part2. Characteristics of type2diabetes mellitus in the newly diagnosed patients of different age groupsObjective:To investigate the clinical metabolic characteristics of type2diabetes mellitus (T2DM) in newly diagnosed patients of different age groups.Methods:2908individuals with no previous medical history of diabetes mellitus were included in the analysis, all of which were described as T2DM by75g oral glucose tolerance test (75gOGTT) according to the diagnosis criterion of WHO1999. These newly diagnosed DM patients were divided into three age groups:youth (...