Study Of The Characteristic And The Related Risk Factors Of Coronary Artery Changes In Elderly Patients Of Coronary Heart Disease Complicated With Insulin Resistance

Objective To Study the characteristic and the related risk factors of coronary artery changes in elderly patients of coronary heart disease complicated with insulin resistance. Methods There were one hundred and seventeen elderly patients of coronary heart disease in the research, measure their height, heavy, the stomach round, blood pressure, fasting blood glucose ( FPG), fasting insulin( FINS), high density lipoprotein cholesterol (HDLr C), total cholesterol(TC), triglyceride (TG), insulin resistance was assessed by homeostasis model assessment (HOMA) , the following formula: IR= fasting blood glucose ( mmol/ 1) × fasting insulin( mU/ L) ÷ 223, the patients with the IR ≥2.69 were indicated as coronary heart disease complicated with insulin resistance (CHD+IR)group, and the patients with the IR <2.69 were indicated as coronary heart disease complicated with insulin sensitivity (CHD+IS)group. All patients were examined by coronary angiographic semiquantitative(CAG), The related risk factors in coronary artery disease were analysed by pluralism straight line statistics. Result The level of IR was correlated with the levers of body mass index (BMI), hypertension, fasting blood glucose ( FPG), fasting insulin( FINS), high density lipoprotein cholesterol (HDL- C), total cholesterol(TC) and triglyceride (TG). The coronary multivessel changes and the severity of coronary artery stenosis were more frequent in the IR group than those in the IS group. Distal coronary change was more frequent in the IR group than that in the IS group . Hypertension, fasting blood glucose ( FPG), fasting insulin( FINS), total cholesterol( TC) and triglyceride (TG) were positively and high density lipoprotein cholesterol (HDL- C) was negatively correlated with the coronary artery lesion. Conclusion The occurrence of coronary multivessel changes and the distal coronary changes were more frequent in the IR group than those in the IS group. These results suggest that insulin resistance, hyperlipemia and hypertension are all independent risk factors for the coronary artery disease.