Relationship Between Insulin Resistance And Contrast-Induced Nephropathy In Non-Diabetic Patients After Coronary Angiography/percutaneous Coronary Intervention

Objective: To investigate relationship between insulin resistance(IR)and contrast-induced nephropathy(CIN)in non-diabetic patients after coronary angiography/percutaneous coronary intervention.Methods: A total of 153 non-diabetic patients underwent elective coronary angiography(CAG)/percutaneous coronary intervention(PCI)in ZHONGDA HOSPITAL SOUTHEAST UNIVERSITY from June 2019 to November 2019 were selected into this study.We recorded FPG、FINS、serum creatinine(Scr)before CAG/ PCI,tested Scr again 48-72 hours after CAG/ PCI.Patients were divided into IR group(HOMA2-IR≥1.4,n =72)and control group(HOMA2-IR<1.4,n=81).According to the occurrence of CIN,the patients were slao divided into CIN group(n =15)and non CIN group(n =138).Using multivariable logistic regression analysis to analyze the relationship between IR and CIN.Results: 15(9.8%)patients developed CIN among the whole 153 patients.CIN occurred in 11(15.28%)patients in the IR group,while in the control group,CIN occurred in only 4(4.94%)patients.The incidence of CIN was significantly higher in IR group than control group(P=0.030).The ratio of IR in CIN group(73.33%)was significantly higher than non CIN group(44.2%,P=0.030).Multivariable logistic regression analysis showed that HOMA2-IR(P=0.039,OR=1.485,95%CI=1.019-2.163)was an independent risk factor of CIN.The receiver operating characteristic curve(ROC)of HOMA2-IR predicting CIN after CAG/PCI indicated the area under the curve(AUC)and 95%CI were 0.675,0.520-0.830.Conclusion: The rising HOMA2-IR may increase the incidence risk of CIN after CAG/PCI for patients with IR.HOMA2-IR is an independent risk factor for CIN.HOMA2-IR has certain predictive value for CIN after CAG/ PCI.