Comparison And Evaluation Of Different Staging System Of Hepatocellular Carcinoma Treated With Traditional Chinese Medicine

Objective: To compare and evaluate the discrimination and prognostic efficacy of several staging systems of hepatocellular carcinoma (HCC) treated with traditional Chinese medicine (TCM).Method: Ninety-four patients were recruited whom were admitted by Guangdong Province Hospital of Traditional Chinese Medicine from Jan 1997 to Oct 2004. The end time is the death time, and five patients were excluded because of losing follow-up or not dying of HCC. All of them were assured to be hepatocellular carcinoma through histological diagnosis histological. Staging of each patient was performed at the baseline by using Okuda, French Staging, CLIP, BCLC, TNM, CUPI, and the National Staging (1998). Therapeutic factors were classified to three groups: Best Supportive Cure (BSC), BSC in combination with TCM, TCM in combination with modern medicine therapy. The cumulative proportion surviving of therapeutic factors and these staging systems were analyzed by the Kaplan-Meier statistical method and log-rank test to show their effects and discrimination. According to the common characteristics, symptoms, clinic tests, modalities and staging of these patients, 23 prognosis factors were selected, and they were analyzed by the Cox regression method. Then dangerous factors and protective factors were screened out, which may offer reference for clinical treatment of HCC in the future.Results: The median age of these patients was 55. 50 year old; the minimum age was 19 year old; the maximum age was 86 year old: the male/female ratio was 79/15. The median survival time was 2. 50(1. 79, 3. 21)month; the...