Expression Of SQLE In Hepatocellular Carcinoma And Association With Prognosis Atfer Curative Resection

Hepatocellular carcinoma (HCC) is one of the most common fatal human digestivesystem tumors, the latest survey shows that it ranks the eighth cause of cancer death inEurope and the United States and fifth worldwide. Incidence of Chinese liver canceraccounted for55%of the global, thus the relative research of HCC has great importantmeanings for the promotion of the health of people living in China and worldwide.Curative surgical resection is preferred to HCC treatment, but the high recurrence andmortality has been perplexed to the prognosis of patients survive as the leading cause ofintrahepatic recurrence. So searching for the ideal post-hepatectomy prognostic indicators,and accordingly a reasonable adjuvant therapy are meaningful for prolonging survival ofHCC patients.Traditional liver cancer prognosis rely more on the clinical and pathological data,such as TNM stage, but the clinical indicators are broader, with advanced hepatocellularcarcinoma prognostic significance, but for the pathologically similar features earlyPrognostic, the application was clearly demonstrated inadequate.In recent years, studies have shown that early HCC traditional pathologicalparameters are similar, but recurrence and survival of patients after the situation are quitedifferent, a larger portion of HCC also occur in patients with early recurrence, referred tothe five-year recurrence rate of up to60%. With the wide acceptance in recent years,public health examination heightened awareness and treatment of liver cancer concept(such as the Barcelona Clinic Liver Cancer, BCLC staging), proportion of early livercancer patients in clinical who undergoes surgery is increasing, so looking for earlyPrognostic molecular indicators is particularly important. Although there are more andmore researches, but the real clinical value of hepatectomy molecular markers is stilllimited, especially molecular markers for early HCC is still small.Therefore, to explore new liver cancer metastasis and recurrence of molecularmarkers and to study the mechanism of regulation of proliferation and invasion of livercancer, according to the markers to distinguish between the prognosis of patients hasimportant clinical significance. The study here based on the selected differential expressionof molecular markers in hepatocellular carcinoma which contains our previous gene chipscreening database. And the aim of this stuedy is to identify SQLE, the new moleculesspecifically and highly expressed in HCC tissues (squalene epoxidase), as prognosis ofliver cancer guidance, and to clarify the regulatory mechanism and its related inhibition of the therapeutic effect of the drug on proliferation, invasion, making it liver cancertherapeutic targets to provide theoretical and clinical basis.SQLE (squalene epoxidase) comes from the our early cDNA microarray expressionprofiling results, liver cancer screening high expression of molecules. Its molecular size is57kDa and play its normal function in lipid metabolism. The molecules are moreconcentrated in plants and fungi, plant-specific expression can affect the growth of plantsand some medicinal value of plant molecular synthesis; similarly, SQLE also has effect onkey lipids metabolic enzymes in fungi, making the anti-fungal treatment possible.Therefore, to study SQLE biological traits in hepatocellular and the final transformation ofthe terbinafine, makes specific therapy possible in hepatocellular carcinoma, which has avery important clinical significance and wide range of biological prospects.Based on preliminary studies HCC tissue gene chip high expression of specificmolecular markers database, we selected out SQLE,our results suggested that SQLEexpression is a good predictor of liver cancer, especially for early liver cancer predictionand SQLE may be explored as therapeutic targets.Our study also lay the foundation forfollow-translational medical research.