| Objective To develop the theory foundation for the prevention and handle of the electrocyte disorders in the patients after the resenction of pituitary adenomas according to the measurement of the blood concentration of Sodium, Kalium, Aldosterone(ALD) and Atrial Natriuretic Polypeptide(ANP), and the Sodium, Choloride concentration of the urine were also measured. The analysis of the ralationship between these factors will provide us more knowledge to handle these kinds of disorders.Method 20 patients who had been confirmed as pituitary adenoma patients were randomly selected between October 2002 to December 2002. Plasma ALD and ANP, serum Sodium snd Kalium , urine Sodium and Choloride, were all examined in each patient before and after operation. 7 normal healthy volunteers at the same period were served as controls. Plasma ALD and ANP were also examined. To analysis the difference of plasma ALD and ANP between the pituitary patients before operation , after operation and controls,as well as the changes of serum Sodium snd Kalium , urine Sodium and Choloride , urine volume between the different groups. To study the relationship between the the blood concentration of Sodium and Aldosterone(ALD) , Atrial Natriuretic Polypeptide(ANP) with SPSS , it is statistically different at p<0.05.Results (1)Serum Sodium level dropped in the 45% of the patients afteroperation, with no significant difference found before and after operation. (2)A11 the patients were found that the urine volume and urine sodium and choloride were increased after their operation. It was statistically different; The contrast analysis between the hyponatremia group and non-hyponatremia group indicates that urine sodium level obviously increased in the former group after operation , P=0.002. It was statistically different. In the latter group the level of urine sodium also increased after operation but it was not significantly different , P=0. 364; (3) plasma ALD and ANP level had no significant difference and there was no significant differences in the age, the character of tumor, the size of tumor, surrounding tissue invaded or not. Plasma ANP level of male group were significantly higher than that of female group, P=0.01. The patients were divided into two groups to make a contrast analysis: hyponatremia group and non- hyponatremia group. For hyponatremia group, the basic secretion before operation was more than that after operation. There was no significant difference. But there was significantly difference in contrast with the control group ,p=0.007. The group had no significant difference in the plasma ANP between before and after operation but there was significantly difference corresponding with the control group, p<0. 05. In non-hyponatremia group, the basic secretion of serum ALD before operation was low, but increased after operation ; the ANP level dropped after operation but there was no statistical difference. It needs further investigation for the result may be influenced by the small number of the studied patients.Conclusion There are water-electrolyte disorders before and after operation of pituitary adenoma and these abnormality had a certain relationship with the level of plasma hormones (ALD, ANP et al). These hormones control sodium regulation. Serum sodium level of the patients in the hyponatremia group just slightly decreased before operation because hypersecretion of ALD can keep the balance of electrolyte by reabsorbing sodium and excreting kalium. But after operation, the patients developedsevere hyponatremia because the ALD secretion was decreased by operation. Urinary sodium excretion is increased and sodium reabsorpation is reduced. In the end, there is a sodium deficit in the body. There are other mechanisms playing roles in the redistribution of sodium and it should be studied furthermore. In a summary, there are diverse degrees of hyponatremia and many complex reasons to cause hyponatremia. According to the treatment for hyponatremia after operation, three measures should be taken seriously, that is (1) sodium suppleme...
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