Study Of Coronary Heart Disease Risk Factors In Uygur Nationality With Impaired Glucose Homeostasis

Objective: To investigate coronary heart disease (CHD) risk factors in Uygur nationality with impaired glucose homeostasis (IGH) and its interventions. Methods: 313 subjects were recruited and classified into normal glucose tolerance group (NGT group), impaired fasting glucose and/or impaired glucose tolerance group (IGH group), diabetes group (DM group) according to the World Health Organization criteria. Plasma lipid, glucose and insulin concentrations were measured. Results: In subjects with IGH, the fasting plasma insulin and 2h plasma insulin during an oral glucose tolerance test were significantly greater than in subjects with NGT or DM (P<0.01). There was no statistical difference in total cholesterol, triglycerides, LDL cholesterol or HDL cholesterol between IGH group and NGT group; but according to a homeostasis modal assessment for insulin resistance (HOMA-IR), IGH group was significantly higher than NGT group (P<0.01). Conclusion: Insulin resistance including hyperinsulinemia is a major CHD risk factor in Uygur nationality with IGH. They will require diet therapy and weight reduction.