Effect Of Fixed Xiaocaihutang On Eos And IL-5 Serum Of Guinea Pigs Of Bronchial Asthma

Bronchial asthma , called asthma for short , is a chronic inflammation of bronchia. Many inflammatory cells such as mast cell, eosinophil ,T cell etc. participate in the inflammatory reactions. The main changes in pathology is inflammatory reactions of bronchial mucous membrane ,hyperkinesias of bronchial smooth muscle and a reversible block of bronchia caused by secretion. During the outbreak of asthma, IL-5 and Eos is the important facts when the immune system activated by allergen.. Inflammatory reactions of respiratory tract is the base of hypersensitivity. Many inflammatory cells such as neutrophil, macrophage, eosinophil(Eos ),T cell and B cell etc., inflammatory medium and cytokine participate in the inflammatory reaction.In therapeutics , it is realized that the method that use ?-receptor activator, aminophylline and anti -cholinomimetic drugs etc. to relieve hyperkinesias is not all around. It is the essential measurement that use corticosteroid drugs treating the hypersensitive inflammation to prevent the onset of asthma. But the long term use will lead to the sthenic symptom of corticosterone function. Inhalation will lead to the side.effect as hoarseness, thirst and drug resistance. Recently, research shows that, the incidence and mortality of asthma are increasing in world wild. Therefore, using fixed Xiaocaihutang to treat asthma have the practical significance in clinic through the function of immunity regulating under the guidance of traditional Chinese medicine theory.In order to explore the mechanism and effect of fixed Xiaocaihutang in treating immunity of bronchical asthma, the experiment was developed. The guinea pig model of bronchial asthma was built up. The effect of fixed Xiaocaihutang, aminophylline on the guinea pig of bronchial asthma were observed, and total cells inthe bronchoalveolar lavage fluid(BALF), eosinophils(Eos)count , IL-51ever were tested. Results show that: Bronchical asthma model group compared with the control group, IL-5 serum lever (P <0. 01) inthe asthma group showed higher than those in the control group; the group of Xiaocaihutang compared with the model group, decreasing the total cell, Eos count and IL -4 lever(P <0.01); there is cooperation between Xiaocaihutang and aminophylline(P<0. 01).It can be concluded that, Immunological adjustment of Xiaocaihutang in treating bronchial asthma was finished by regulating the immune function, resisting IL-5 lever and decreasing Eos count. Both Xiaocaihutang and aminophylline increased the function of treating'bronchial asthma. It not only can relieve the smooth muscle of bronchia, but also can regulate the immune function through suppressing immunocyte to producing IL-5 etc. Therefore, it can treate the inflammatory reactions of respiratory tract, decrease the hypersensitivity of respiratory and suppress the asthma. The experiment provide a evidence on molecular pharmacology for clinic in treating asthma, but the detail is waiting for more research.