| Background:China is one of the highly epidemic areas for hepatitis B virus infection. Investigations indicated,there were more than 700 million people had infected hepatitis B virus,and about 130 million people carried hepatitis B surface antigen. Among this people about 20 million would die of hepatitis B or the diseases related to hepatitis B virus infection. In China, about 240 thousand people would die earlier because of HBV infection. More than 4 million life-year lossed and about 216.17 million yuan direct medical consumption was also related to HBV infection. Therefore, hepatitis B not only seriously damaged the people's health but also greatly wasted the social resources. This had become a big public health problem in China. In order to control the prevalence of hepatitis B all over the world,the World Health Organization(WHO)put forward world hepatitis B immunization project in 1991,and established the strategy target of exterminating hepatitis B before 2010. The most key measure of this project was the hepatitis B vaccine immunization to all newborns. Scholars had done a large amount of research on the safety, immunity original quality, immune effect of hepatitis B vaccine,fully affirmed the protecting effect. The Department of Health promulgated 'The Strategy of Hepatitis B vaccine Immunization' in 1991, brought it into immunity management. This plan had been carried out science January 1, 1992. For any hygiene plan,we should not only devote much attention to its' sociology meaning but also appraise the economics benefit(and the result) that the plan produced. So we should investigate the cost-benefit of every strategy. The result of cost- benefit study was useful for the government to make decision.Objective:The study plans to evaluate the immunization strategy of newborns hepatitis B vaccine in Shijiazhuang city with the method of cost-benefit analysis. The result of this study is valuable for the hygiene department to adjust or perfect immunity strategy, and is valuable for the hygiene resource' usage.Methods:Cost-benefit analysis was adopted to conduct the analysis with the indicator of benefit-cost ratio(BCR).Regarded the natural and social condition of Shijiazhuang as the background,our study followed the traditional routes:(1)Suppose the newborns of Shijiazhuang in 2001 was 100 thousand. Calculated the hygiene resources(including manpower and material resource)used in the immunization strategy of newborns hepatitis B vaccine in Shijiazhuang. This was the cost of this strategy.(2)Calculated the number of hepatitis B patients that would happen in these 100 thousand newborns in their whole lives if we had not given them interpose,and calculates the direct and indirect economic losses of these patients. Combined the data about the incidence of hepatitis B,vaccine inoculating rate,protecting rate to statistic the reduced number of hepatitis B patients and the reduced economic losses because of implementing hepatitis B vaccine immunity in all newborns. Regarded this as the anticipated benefits that the newborns' hepatitis B vaccine immunity.(3)Evaluated the neonates hepatitis B vaccine immunology prevention strategy in Shijiazhuang with the method of cost-benefit analysis with CBA. And carried on sensitiveness analysis to this strategy,evaluated the feasibility of this strategy from the hygiene economics. Results:The calculation showed that there would be 5.4058 million yuan used in hepatitis B vaccine immunity for 100 thousand newborns and the pregnant women examining. The average direct economic loss for a hepatitis B case was 5324.40 yuan. And 7.61 DALY lose for a hepatitis B patient,which means 52.80 thousand yuan indirect economic loss. The direct economic benefit of the neonates' immunology prevention strategy against hepatitis B was 16.1010 million yuan, and the whole economic benefit of this strategy was 175.7682 million yuan. The BCR of this strategy was 32.52,the benefit of this strategy was very good. When the price of hepatitis...
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