| Objective To investigate the mechanism of ear acupuncture by studying the effects of acupuncture of "thoracopneumatic area" (TPA) on the cardiovascular activity of nucleus paragigantocellularis lateralis(PGL) in rabbits . Methods The experiments were performed on 40 rabbits anesthetized with Urethan. The mean arterial pressure(MAP)x left intraventricular pressure(LVSP) , maximum rate of intraventricular pressure change(LV+dp/dt max), heart rate(HR) and renal sympathetic nerve discharge (RSND) were recorded. When microinjection into PGL induced the changes of cardiovascular activity, the effects of acupuncture of TPA on these changes were observed. Results (1) When NS was microinjected into PGL, MAP, HR, LVSP, LV+dp/dt max, RSND did not change significantly. When NS was microinjected into PGL with acupuncture in TPA or nTPA simultaneously, RSND increased, MAP, HR, LVSP, LV+dp/dt max did not change significantly. (2) The microinjection of Glutamate(Glu) into PGL brought about the increase of MAP, LVSP, LV+dp/dt max and RSND. While the microinjection of Glu into PGL with acupuncture in TPA simultaneously, the extent of the variabilities of MAP, LVSP, RSND were reduced and the extent of the variabilities of LV+dp/dt max was not changed. (3) The microinjection of Glutamate(Glu) into PGL brought about the increase of MAP, LVSP, LV+dp/dt max and RSND. While the microinjection of Glu into PGL with acupuncture in nTPA simultaneously, all of the variabilities of MAP, LVSP, LV+dp/dt max and RSND were not changed significantly. Conclusion (1) Acupuncture of "thoracopneumatic area"on anesthetized rabbits can regulate the cardiovascular activities that were produced by the excitation of Glu through the microinjection of Glu into to PGL, and sympathetic vasoconstrictor center may be2responsible for this regluting action. (2) There was specialty of regluting action between "thoracopneumatic area" and "non-thoracopneumatic area".
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