| [Objective] Acute stroke has high disease incidence and mortality which threatens human health and life quality. Early diagnosis and therapy are very important. In this study, 71 cases of different time stroke were collected and performed MRI scan. Our purpose is to discuss diagnosis value of DTI in different time stroke.[Materials and Methods} 71 cases of stroke were divided into four groups according to different time: (1)<=12 hour; (2) >2~24hour; (3) > day~3 days (4)> days~7days. All of cases were performed MRI plain scan(axial ,sagittal Tl-weighted images and axial,coronal T2-weighted images and axial diffusion-weighted images) and DTI. 6 cases performed reexamination after therapy. DCavg/FA/1-VR of ROIs' in gray and white matter of lesion side and contralateral side and ROIs' in central and peri parts in the lesion were measured. To calculate the Pearson correlation and the significant difference between each parameter of lesion side and contralateral side, then use the paired samples t-test. The parameter or parameter ratio of the other parts was performed test of homogeneity of variances, then use ANOVA, p value less than 0.05 was considered significant. 10 cases were performed 3D reconstruction of bilateral CST by DTV and analysis the relationship between the lesion and adjacent fiber matter. [Results]1. The DCavg of lesion side were decreased compared to contralateral side. The DCavg of 42 gray matter(GM) ROIs' and contralateral ROIs' were 4.765 ?1.120 and 7.467?1.301 (mean盨D),paired samples t-test showed significant difference between infarct GM ROIs' and contralateral GM ROIs' (.PO.001). The DCavg of 39 white matter(WM)ROIs' and contralateral ROIs' were 3.456+1.221 and 7.588 ?.982,there was significant difference between them(P<0.001). The DCavg of WM infarct reduced more significantly. The DCavg of normal GM and WM were not significant difference(.P=0.90). The ANOVA method showed significant difference between first and forth group(.P<0.01). The DCavg were significant difference between central and peripheral part of the lesion in first and second group. ANOVA method showed significant difference between first two groups and forth group.2. FA/RA/1-VR of 6 cases in the first group elevated compared with contralateral side, and it had significant difference between both of them. It had tendency which central part elevated compared with periphral part, but no significant difference was found.3. FA/RA/1-VR of the cases in the others groups reduced compared with contralateral side. There were not significant difference between the GM ROI and contralateral side in 35 ischemia lesions. There were significant difference between the WM ROI and contralateral side in 37 ischemia lesions. FA/RA/1-VR in normal GM and normal WM were significant difference. Changes in FA/RA/1-VR in third and forth group were significant. ANOVA method showed significant difference between first group and the others groups.4. FA/RA/1-VR in central part increased compared with periphral part in the second group cases, and the changes were significant. Smilar findings were found in third group, but they were not significant. FA/RA/1-VR in central part decreased compared with periphral part in the forth group cases, and the changeswere not significant. ANOVA method showed significant difference between forth group and the others groups.5. 6 patients reexaminated after therapy. FA/RA/1-VR in periphral part increased compared with before therapy in 4 cases of 6 cases, their DCavg still showed decreased. The other 2 cases showed no obvious change.6. 10 cases whose lesions located basal ganglion, splenium of the corpus callosum, brain stem and cerebral hemisphere performed 3D reconstruction of white matter tract. 5 of 10 cases CST showed no compress and disruption, whose myodynamia were normal. 2 of 10 cases CST were compressed and not disrupted, whose myodynamia recovered after therapy. 3 of 10 cases CST were disrupted, whose myodynamia had not recovered. 2 of 10 cases also observed other fiber trac...
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