The Resonance Imaging Study Of Diffusion Tensor Magnetic On White Matter Fiber Cinnections Of Brain Of Depression Patient Treated By Medicine

Background：Depression is a common affective mental illness, withthe characteristics of high morbidity, recurrence rate, high morbidity, highmortality rate, while low cure rate of serious harm to human physical andmental health, burden social financial cost. At present, the study ofdepression involves many disciplines, but there is no unified conclusion.Purpose: By means of magnetic resonance diffusion tensor imagingtechniques and combine with tract-based spatial statistics(TBSS) analysisthe DTI data of young patients with major depression who were notuntreated medicine primarily, meanwhile to explore white mattermicrostructure and abnormal fiber connection, to investigate the possibleetiology and pathogenesis of depression. Method: Totally include32cases (11male,21female) in line with the DSM-IV major depressivedisorder diagnosis standard major depression patients and55age-andgender-matched healthy people, to handle of the17-items of HamiltonDepression Scale (HAMD-17) and Beck Depression Inventory (BDI)assessment. Depressive patients, HAMD-17＞18, BDI＞8, meanwhile thecontrol group of HAMD-17＜8, BDI≤4. To deal the DTI scan on doublegroups, by TBSS method based on fiber bundles tracer, to compare thewhite matter and fiber connections fractional anisotropy (FA) between patients and control. Result: The results displayed that the brain areawithin depression group, the right precentral gyrus, left precentral gyrus,right inferior frontal gyrus, right superior occipital gyrus and right insulacortex white matter FA values were lower than the normal control group (P<0.05, voxe1＞50); while left and right longitudinal fasciculus, the rightInferior fronto-occipital fasciculus, right uncinate fasciculus and left andright corticospinal tract FA values lower than the control group. Not anyFA values of white matter of patient were higher than the control.Conclusion：1. There are white matter damage on frontal and temporal lobeon youth depression patients who were not treated medicine.2. The parts ofleft and right longitudinal fasciculus, the right inferior fronto-occipitalfasciculus, right uncinate fasciculus and left and right corticospinal tractthat connect were damaged youth depression patients who were not treatedmedicine.3. The white matter microstructure and fiber connectivityabnormalities were occurred in early phase of depression on depressionpatients.4. The medial prefrontal cortico-striato-pallid-thalamic tractabnormalities may be one of the reasonable factors leading depression.