The Observation On Postprandial Coagulation Activation And Its Influencing Factors In Type 2 Diabetes

Objective: To evaluate the effect of post-meal hyperglycaemia on markers of coagulation, fibrinolytic activation: Thrombin time (TT) , Prothrombin time(PT), Activated partial thromboplastin time(APPT), Fibrinogen(FIB) and D-Dimer (D-D). Methods: Forty type 2 diabetes maintained on diet therapy alone were followed a standard meal. Blood samples for measurement of plasma glucose(BG), insulin(INS),TT, PT, APTT, FIB, D-D were drawn at fasting state(FBG, FINS, FTT, FPT, FAPTT, FFIB, FD-D)and post-meal 2 hours(PBG, PINS, PTT, PP, PAPTT, PFIB, PD-D). Multifactor stepwise regressive analysis was performed on postprandial coagulation, fibrinolytic factors of type 2 diabetes. Results: Hyperglycaemia and hyperinsulinemia after a standard meal was accompanied by a significant decrease of plasma concentration of PTT, PPT, PAPTT(P<0.001) and marked increase of PFIB , PD-D(P<0.05) in comparision to their baseline values. Multifactor stepwise regressive analysis showed that PD-D had remarkable correlation with FD-D and PBG. Conclusion: Post-meal hyperglycaemia at the level reached by many diabetic patients on diet therapy alone, induces a activation of coagulation and successive accentuation of fibrinolysis. Postprandial markers of coagulation, fibrinolytic activation had remarkable correlation with its baseline values and postprandial glycaemia.