Expression Of FHIT, Bax And Ki67 And Clinical Significance In Cervix Carcinoma

Objective To investigate the expression of FHIT, Ki67 and bax and their relationship with clinicopathologic parameters and prognosis in cervix carcinoma.Methods Immunohistochemical analysis was performed in 50 invasive cervix carcinomas and 20 normal cervix tissues.Results Compared to normal cervical tissues , expression of FHIT protein was significantly reduced or absent in invasive cervical carcinomas(P<0.001). Reduction or absence of FHIT expression was found in 52% (26/50) of the tumors. Positive staining of Ki67 was detected in 36 of 50 (72%) cervical carcinoma. Bax immunoreactivity was observed in 31 of 50 (62%) cervical carcinoma. Loss of FHIT protein was closely related with histological grade(P = 0.003) and lymph node metastasis(P = 0.032), as well as disease recurrence and death(P=0.019), but not to the age, stage and histologic type (P>0.05) . No relationship was found between Ki67 expression and clinicopathological parameters and survival. The expression of bax increased with histological grade(P = 0.012), but wasn't related to age, stage , histologic type, lymph node metastasis and survival. There was a positive correlation between FHIT and bax (rs=0.340, P=0.016), a negative correlation between FHIT and Ki67 (rs= -0.292, P=0.039).Conclusions FHIT protein expression is reduced or absent in the majority of cervical carcinomas. Loss of FHIT expression is associated with higher malignant phenotypes. FHIT may be involved in the development of cervical carcinoma by regulation of apoptosis and proliferation. Furthermore, reduced expression of FHIT was associated with a poor outcome. Bax and Ki67 may play an important role in development of cervical carcinoma, however they did not contribute to prognosis.