Study On Correlation Between The Expressions Of Cyclooxygenase-2 And P53 In Human Colorectal Carcinoma

Objective: This study was designed to investigate the expressions of COX-2 and p53 in human colorectal carcinoma and their correlations with clinicopathological features of colorectal carcinoma. Methods: The expressions of COX-2 and p53 were determined by immunohistochemical staining in 72 surgical specimens of colorectal carcinoma and 21 normal mucosal tissues. Results: (1) The positive rates of COX-2 and p53 in colorectal carcinoma were 70.8% and 62.5%, respectively. The differences between carcinoma group and normal tissues group were statistically significant (p<0.05). (2) The expressions of COX-2 were significantly higher in lymph node metastasis group , liver metastasis group , Dukes C, D group than in their counterparts (p<0.05); the expressions of p53 were significantly higher in lymph node metastasis group , liver metastasis group , poor differentiation group than in their counterparts (p<0. 05). (3) There was a significant correlation between the expressions of COX-2 and p53 (p<0. 01). Conclusions: (1) The abnormal expressions of COX-2 and p53 play a role in the carcinogenesis and development of colorectal carcinoma. (2) The expressions of COX-2 and p53 show a positive correlation in the carcinogenesis and development of colorectal carcinoma, the mutation of p53 might be the one of important factors in the COX-2 overexpression of colorectal carcinoma. (3) COX-2 and p53 can be used as markers for carcinoma metastasis. Detecting the expressions of COX-2 and p53 is helpful to evaluate the biological behavior of colorectal carcinoma, and also provides the evidence for clinic treatment.