| Losing blood in operation and presence of hypovolum areproblems which are usually met in the surgical opcration.In therecent years, in order to save blood and reduce the bad influence oftransfusion with others' blood , acute hypervolemichemodilution(AHHD)has been a major way of protecting bloodand decreasing volume of transfusion with others' blood .Now,6% hydroxyethl starch (HES) and 4% gelofusine are thought ofsate and effective colloid in clinical use arid being able to use inAHHD.They have excellent effection on volume of blood, littletime of staying in bodv,few effection on blood coagulation andrenal function and low presence of allergy.We chose thirty patientswho are given AIIItD before operation and had a clinicalobservation of their renal funation Just for analyzing the eftectionof AHHD on the patients' renal function Thirty patients are ASA I-II ,who were to undergo electiveoperation of gastric cancer or rectum cancer ,and their ages arebetween 50-65 years, their weights are between 50-80Kg.Theylave normal function of heart, lung, liver, kidney and don't havehypertension Hb>110g/L, Hct>3%. The hemorrhagic volume is;between 400-800ml, which need not blood tranfusion but onlycolloid,The patients were divided into three groups in random: Rgroup(Ringers' solution group) ,H group(HES group) ,Ggroup(Gelofusion group ).Gennral anesthesia was adosed,allpatients received pre-meaication with scopolamine 0.3 mg im.before "induction of anesthesia.Induction of anesthesia withFantany14 g/Kg, Nocuron 0.1-0.2 mg/Kg, Midazolam 0.1 mg/Kg,Propofol, 1-2 mg/Kg iv., then tracheal intubation. Maintenance ofanesthesia with N20:O2 1:1 ,and Enflurance 1~2%, according tothe need of operadon, Fantanyl, Nocuron Propolbl iv,. to maintainwell depth of anes besia . until 30 minutes before the end ofoperation. After the induction of general anesthesia, make theright jugular vein cannulation and continuously monitor the centralveinous pressure(CVP) ; at the same time ,monitor the heart rate(HR), blood pressure (BP), mean aerial pressure (MAP). In thestable condition after the induct on of general anesthesia, in Hgroup 6%HES 20ml/Kg was infused in the speed of80~100ml/3min before operation, followed by Ringer's lactate solution in order to make the acute hypervolemic hero,dilution. InG group, did the same thing with 4% Gelofusion. In control group(R group) only Ringer's lactate solution was infused, in operation,we adjusted the speed of Ringer's lactate solution aecording to thechange of HR and BP, and adjusted the inhaling concontration ofEnilurane,injected discontinuously Propofol into vein to relax theperipheried vessel and to maintain blood circulation siable(thedecreasing of SP and the increasing of HR are not beyond 25% ofthe basic value MAP is not below 70mmHg, CVP is stablebetween 8 to14 cmH2O ). If CVP>16 cm I2O,we stopped theexperiment of this patient and deleted it. After operation, thepatients were infused Ringer's lactate solution usualy and weregiven blood trarsfusion if it was necessary. Inspected andmemorized the followings: (1)the value ofHR, SP, DP, MAP, CVPbefore HHD and every 30 minutes after beginning of AHHD (2)the value of Scr and BUN before AHHD (To), at the and ofoperation (T1), on the first day after operation (T2). on the third dayafter operation (T3); the value of M in blood and in urine at Tand T1. (3) the accumulated volume of transfusion requiremend (Ringer's lactate solution and colloid ),blood losing and urineduring every time part in the operation. The results were expressedwith ,statistic analysis was performed with T test toexamine intergroup and within group differences, just forintergroup and within group comparisons:. The P value <0.05 wasconsidered statistically significant. Result: All the patients of thethree groups have no differences in the fol...
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