| Heptaocellular Carcinoma is one of the most familiar malignant tumors in the world. It is the fifth most common neoplasm in the world, and the third most common cause of cancer-related death, More than 500 000 new cases are currently diagnosed yearly. Treatments for HCC have been conventionally divided into curative and palliative. Many other treatments cannot achieve response rates and outcomes comparable to surgical treatments, hepatic resection is the best option for HCC. In our research, we have evaluated the effect of hepatectomy under direction of ultrasound guided segmental dye staining combined with intraoperative chemotherapy following segmental portal vein branch occlusion by balloon catheter.Material and methods:46 cases of heptaocellular carcinoma were randomized into two groups, in group A 21 cases treated by ultrasonically guided segmentectomy and intraoperative chemotherapy following obstruction of segmental portal vein and injection of dye, and in group B 26 cases treated by normal hepatectomy. In group A, 13 of 21 cases were huge HCC with single region (diameter>5cm) cases, 4 of 21 cases were huge HCC with multiple regions cases, 4 cases were small primary hepatic carcinoma of 3cm in diameter. 17 cases were male and 4 cases were female. Average age is 55.2. The liver function of 16 cases was judged into Child pugh class A, the liver function of 5 cases was judged into Child pugh class B. all this cases had no tumour embolus in portal vein. In group B, 17 of 25 cases were huge HCC with single region (diameter>5cm) cases, 3 of 25 cases were huge HCC with multiple regions cases, 5 cases were small primary hepatic carcinoma of 3cm in diameter. 22 cases were male and 3 cases were female. Average age is 55.2. The liver function of 20 cases was judged into Child pugh class A, the liver function of 5 cases was judged into Child pugh class B; all this cases had no portal vein tumor thrombosis. In each patient, peripheral venous blood was drawn for liver function tests, serum AFP determination, serum LDH and LDH1 determination on definite time point: preoperative phase, postoperative day 1, postoperative day 3 and postoperative day 7, and so on. We also compared the complication and survival time between hepatectomy under direction of ultrasound guided segmental dye staining combined with intraoperative chemotherapy following segmental portal vein branch occlusion by balloon catheter and the treatment of normal hepatectomy. Experimental data were presented as mean + standard deviation. ANOVA and independent 2-tasled t-test were performed with SPSS for continuous data. Chi-square statistic was used to test for differences in data expressed as frequencies. A P-value less than 0.05 was considered significant.Results:1. There were not any significant differences in average operative stage between group A and group B(P>0.05).2. The intraoperative blood loss of group A was significant less than the intraoperative blood loss of group B(P<0.05).3. There were significant differences in postoperative liver function and postoperative recovery between group A and group B(P<0.05).4. There were not any significant differences in 2-year survival rate and local recurrence rates between group A and group B(P>0.05). Discussions and conclusions:Treatments for HCC have been conventionally divided into curative and palliative. Curative treatments, such as resection, liver transplantation, and percutaneous ablation, induce complete responses in a high proportion of patients and are expected to improve survival. Palliative treatments are not aimed to cure, but in some cases can obtain good response rates and even improve survival. Many other treatments cannot achieve response rates and outcomes comparable to surgical treatments, hepatic resection is the best option for HCC. It is a big problem for our research that how to protect the liver function during curative hepatic resection.In our research, hepatectomy under direction of ultrasound guided segmental dye staining combined with...
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