The Study Of QZXYKL In Pharmacology

QZXYKL is a being developed pharmacon , which is based in herb mixture and composed of Huangqi, Shanzhi, Fulin, Zexie, Dangui et al. Whose efficiency has been comfirmed clinically. This study researched the main pharmacology of antalgesic, anti-inflammatory and it's mechanism, antibacterial, immunology, and anti-urinary tract infection.1 QZXYKL could significantly decrease the frequency of writhings, and licking time (II) of formalin test; QZXYKL could also delay the latent period of hot plate and tail-curl latency.2 QZXYKL could inhibite dimethylbenzene-induced swelling degree of ear in mouse; QZXYKL could inhibite turpentine-induced proliferation in rats; QZXYKL could inhibit the increased capillary permeability of mice; QZXYKL could inhibite claws swelling in rats with carrageen .In rat model of carrageen-induced swollen, QZXYKL could reduce the contents of MDA in paw tissue and serum, and reduce the contents of PGEa in paw tissue and serum.3 QZXYKL could enhance the proliferation of murine lymphocytes induced by ConA or LPS.The function of antibody-forming cell was also promoted after the administration of QZXYKL.4 In vitra QZXYKL has bacteriostasis of most common bacterial in UTI. hi vivoQZXYKL can reduce the death rate of the mice infected by Escherichia coli or staphylococcus.5 On the rat's model of Urinary tract infection, QZXYKL could increased urine volume,and decreased the quantity of bacteria; QZXYKL could ameliorated histopathologic examination of kidney and bladder; QZXYKL could decreased the quantity of IL-6 and IL-8 in serumConclusion : QZXYKL has analgesic, anti-inflammatory , antibacteria, improve the immunological function and anti-urinary tract infection effects.