A Study About Inducing The Regeneration Of Alveolar Bone By Filling Extraction Socket In Dog With RhBmp-2/ploylacid Composite

Objective To find a new practical material which can improve the regeneration of alveolar bone by filling rhBmp-2/polylacid composite in extraction soket of dog. Methods rhBmp-2/ploylacid composite was implanted in extraction socket, as was compared with normal healing extraction socket, x-ray evaluation and histological observation and scanning eletronic microscope examination were used to evaluate composite's effects on inducing the regeneration of alveolar bone. Result After 6 weeks, in groups rhBmp/polylacid, bulk bone could be obviously observed ,its image density was close to the bone around extraction soket and higher than control groups., x-ray evaluation and histological observation found extraction sockets filled with composite healed better and more bone was regenerated than control side. After 10 weeks , in groups rhBmp/polylacid, image density of bulk bone was higher than that of bone around extraction soket.Histological observation found extraction sockets filled composite healed better and more bone was regenerated than control side, scanning eletronic microscope examination found that after 6weeks , composite jointed closely with regenerated bone and they had bone interface, after 10 weeks regenerated bone matured, composite was biodegraded. Conclusion rhBmp-2/ploylacid composite can serve as a new biological material in inducing the regeneration of alveolar bone and improving the healing of extraction socket.