Expression Of Vascular Endothelial Growth Factor-C In Breast Cancer Samples And Its Clinical Pathological Significance

Objectives: 1, To study the expressions of VEGF-C and MVD in breast cancer and their correlation with the invasion,metastasis and prognosis of breast cancer.2, To investigate the mammographic features of the breast cancer and correlation between the mammographic features and the expressions of VEGF-C,MVD,ER,and try to provide clinical criteria for selecting pations for appropriate local treatment.Methods: 1 , A totle of 50 patients with breast cancer, comfirmed by both mammography and pathology, was rolled in this study. We investigated the expressions of VEGF-C and MVD by immuno-histochemical staining. 2. To analyze the mammographic features and the expressions of VEGF-C,MVD,ER.Results: 1 , Of 50 cases, lymph node non-metastasis was seen in 19cases, of which VEGF-C positive expre- ssion was seen in 9cases(47%).In 31eases of lymph node metastasis,24 cases were expressed VEGF-C (77%).The VEGF-C expression of group with lymph node metastasis was significantly higher than that of groupwithout lymph node metastasis( p<0.05 ). The level of MVD in group of VEGF-C-positive expression was 31.67 卤 7.85 , in group of VEGF-C-negative expression was 26.84 卤 7.03.The difference between them was distinct ( p<0.05 ). The level of MVD in group of lymph node non-metastasis was 25.56 卤 5.87, which had distinct difference contrasted with group of lymph node metastasis(p<0.05 ) . There was no statistically significant difference between the expressions of VEGF-C,MVD and clinical stage, tumor size, pathologic features.2 > Of 50 cases,17cases were seen to express ER, in whith VEGF-C positive expression was seen in 9 cases (47%), The VEGF-C expression of group with ER-negative expressions(76%) was significantly higher than that of group with ER-positive expressions (p<0.05).Spicule sign were seen in 30 cases, in which 24 cases were seen to express ER. ER expression of group with Spicule sign was significantly higher than that of group without Spicule sign ( p<0.05 ) .But no significant difference was found between VEGF-C and spicule sige,calcification.Conclution:There are clinical significance between VEGF-QMVD expressions and lymph-node metastasis in breast cancer. VEGF-C, MVD and ER were of clinical significance in evaluating lymph node metastatic potency and prognosis. The mammographic findings of breast cancer were characteristic.They were closely correlated with the clinicopathologic findings.To some extent, thechoice of treatment could be based on these mammographic findings.