The Serum Concentrations Change Of IFN-γ, IL-10 And IL-4 Of Coronary Heart Disease And The Relationship Between These Three Cytokines And Lipoprotein And Fasting Blood Sugar

Objective: To measure serum interferon-gamma, interleukin-10 and interleukin-4 to assess their correlation with coronary heart disease, and to find the correlation between these three cytokines and serum concentrations of lipoprotein and fasting blood sugar. Methods: 28 people without CHD (control group) were studied, and CHD was excluded by coronary angiography or ECG exercise test combined with Holter ECG. 28 patients (CHD group) diagnosed by coronary angiography with narrow coronary artery were also studied. The two groups were matched with sex and ages. The serum concentrations of lipoprotein and fasting blood sugar were measured. The serum concentrations of IFN-γfrom both groups were studied by enzyme linked immunosorbent assay (ELISA), and IL-10 and IL-4 were studied by radio-immunoassay. Results: The serum concentrations of total cholesterol, triglyceride, fasting blood sugar showed no significant differences between the CHD group and the control group (P>0.05). The serum concentrations of low-density lipoprotein-cholesterol (LDL-C) were higher in the CHD group compared with the control group (P<0.05). The serum concentrations of IFN-γwere higher in the CHD group compared with the control group(P<0.001). The serum concentrations of IL-10 showed no significant differences between the CHD group and the control group (P>0.05). The serum concentrations of IL-4 were higher in the CHD group compared with the control group (P<0.05). In the CHD group, the serum concentrations of IFN-γ and IL-4 did not correlate with lipoprotein and fasting blood sugar, however, the serum concentrations of IL-10 had positive correlation with LDL-C. Logistic regression showed IL-4 and IFN-γ were risk factors for CHD (P<0.05). Conclusion: The increased concentrations of IFN-γ and IL-4 can contribute to the genesis of CHD. Endogenous IL-10 cannot retard the genesis of CHD. The serum concentrations of IFN-γ and IL-4 did not correlate with the metabolism of lipoprotein and fasting blood sugar. The abnormal metabolism of lipoprotein affects the serum concentrations of IL-10.