Resolution Of Infectious Parameters After Antimicrobial Therapy In Patients With Ventilator Associated Pneumonia

Objective: the aims of the present study were to describe the clinical and microbiological response to appropriate antimicrobial therapy in patients with ventilator associated pneumonia(VAP).Methods: a prospective study in 23 patients with VAP was conducted, changes of infectious parameters(highest temperaturer,leukocyte count in peripheral blood,quantitative culture result of endotracheal aspirate) after antimicrobial therapy in patients. Empirical antimicrobial therapy was given according to the attending physician and modified according to the results of culture and sensitivity. The outcomes of infectious parameters in patients with VAP were assessed.Results: all three parameters of infection improved significantly with time, the mean duration to resolution of parameters of number of cfu/ml, temperaturer, leukocyte count was 9.78d,7.42d,8.75d,respectively. 95%CI:9.78±1.40d,7.42± 1.66d,8.75±1.94d,respectively. the mean duration to complete resolution of all parameters was 9d.Contusion: a shorter duration of therapy would reduce the super-infection, antimicrobial resistance,the risks of adverse drugs events and health care costs.