A Clinical Application Of Recombinant Human Growth Hormone To Chronic Heart Failure

Objective: To assess the safety and the effect of recombinant human growth (rhGH) on cardiac function in the treatment of patients with dilated cardiomyopathy(DCM) and ischemic cardiomyopathy(ICM) Methods: thirty patients with DCM and ICM were studied at baseline and after a month therapy either with rhGH (n=15,4IU QOD,i.h.)or routine therapy (n=15).Cardiac function was assessed with echocardiography and cardiodynamics. Results: rhGH improved left ventricular systolic function(P<0.05),but no difference between rhGH therapy group and placebo group in diastolic function(P>0.05). Conclusion: rhGH administered to patients with DCM and ICM was safe ;rhGH improved LV systolic function.