A Case-Control Study On The Risk Factors Of NTDs In Shanxi Province

Objectives: To understand the risk factors of neural tube defects (NTDs ) and make a effective measure for protection.Methods: A case-control study was conducted. 152 puerpeants with NTDs as a case group and 152 puerperants with normal newborns as a control group, were collected from 27 counties of higher incidence of NTDs in Shanxi. The risk factors of NTDs were analyzed using the logistic regression.Results: Single variable logistic analysis showed that protecting factors were high educational level, fresh vegetable and fruits, and risk factors were the parental relatives with NTDs, gravidities, parities, fever, viral disease, hyperemesis grvidarum, threatened abortion, hypoemia, agricultural chemicals, fertilizer, yawp, sulfnamids, antibiotics, contraceptives, meclizine, budding potato, husband smoking. The multi-variables logistic regression analysis showed that fever, viral disease, agricultural chemical, fresh vegetables, husband smoking were associated with NTDs.(OR= 7.251, 7.840, 5.952, 0.370, 2.209). The statistics analysis also showed that there was dose-response relationship between fresh vegetables and husband smoking with NTDs.Conclusion: Risk factors of NTDs were fever, viral diseases, agricultural chemical and husband smoking, fresh vegetables is a protecting factor.